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State Key Laboratory of Phytochemistry and Plant Resources in West China
CHEN Jijun's Group
CHENG Yongxian's Group
HAO Xiaojiang's Group
LIU Jikai's Group
LUO Xiaodong's Group
QIU Minghua's Group
ZENG Ying's Group
SUN Handong's Group
TAN Ninghua's Group
ZHANG Yingjun's Group
ZHAO Qinshi's Group
LUO Huairong's Group
LI Yan's Group
LI Shenghong's Group
YANG Yurong's Group
XIA Chengfeng's Group
ZHAO Jinhua's Group
QIN Hongbo's Group
WU Bin's Group
XU Gang's Group
ZHOU Jun's Group
LIU Haiyang's Group
XIONG Wenyong's Group
HU Kaifeng's Group
LI Fei's Group
Location: Home > State Key Laboratory of Phytochemistry and Plant Resources in West China > HU Kaifeng's Group > Major Research Achievements
Major Research Achievements

Major research interest:

Metabolomics, Structural Biology, NMR and LC-MS techniques


Our research mainly focuses on developing and jointly applying liquid state Nuclear Magnetic Resonance NMRand LCMS method in the research of Metabolomics and Structure Biology with the following two main goals

(1) Identification of bioactive equivalent combinatorial components of natural medicines.

(2) Understanding the molecular mechanism of the interactions between bioactive equivalent combinatorial components of natural medicines and their target proteins.


Coupling NMR with LC-MS-SPE, we develop and apply metabolomic protocol for the quick discovery and identification of bioactive compounds, maybe of trace amount, in the crude extract of nature products from traditional Chinese herbs. In addition, we are also interested in discovering key biomarker related to major disease.


For structure biology, our research mainly focuses on the structure and mechanism of the enzymes involved in the nature product biosynthesis and proteins of biological and medical importance. Our goal is to understand the interaction between the enzyme and its substrates, also the interaction between the target protein and small chemicals or antibody.





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