Major research interest:

Metabolomics, Structural Biology, NMR and LC-MS techniques

Our research mainly focuses on developing and jointly applying liquid state Nuclear Magnetic Resonance （NMR）and LCMS method in the research of Metabolomics and Structure Biology with the following two main goals：

(1) Identification of bioactive equivalent combinatorial components of natural medicines.

(2) Understanding the molecular mechanism of the interactions between bioactive equivalent combinatorial components of natural medicines and their target proteins.

Coupling NMR with LC-MS-SPE, we develop and apply metabolomic protocol for the quick discovery and identification of bioactive compounds, maybe of trace amount, in the crude extract of nature products from traditional Chinese herbs. In addition, we are also interested in discovering key biomarker related to major disease.

For structure biology, our research mainly focuses on the structure and mechanism of the enzymes involved in the nature product biosynthesis and proteins of biological and medical importance. Our goal is to understand the interaction between the enzyme and its substrates, also the interaction between the target protein and small chemicals or antibody.