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State Key Laboratory of Phytochemistry and Plant Resources in West China
CHEN Jijun's Group
CHENG Yongxian's Group
HAO Xiaojiang's Group
LIU Jikai's Group
LUO Xiaodong's Group
QIU Minghua's Group
ZENG Ying's Group
SUN Handong's Group
TAN Ninghua's Group
ZHANG Yingjun's Group
ZHAO Qinshi's Group
LUO Huairong's Group
LI Yan's Group
LI Shenghong's Group
YANG Yurong's Group
XIA Chengfeng's Group
ZHAO Jinhua's Group
QIN Hongbo's Group
WU Bin's Group
XU Gang's Group
ZHOU Jun's Group
LIU Haiyang's Group
XIONG Wenyong's Group
HU Kaifeng's Group
LI Fei's Group
Location: Home > State Key Laboratory of Phytochemistry and Plant Resources in West China > LI Fei's Group > Publications
Publications& Representative Publications

 PUBLICATIONS 
  1. Q. Zhao, X. Li, H. Liu, F.J. Gonzalez, F. Li. Metabolic map of osthole and its effect on lipids. Xenobiotica Mar 13:1-38 (2017).
  2. F. Li, W. Zhu, F.J. Gonzalez. Potential role of CYP1B1 in the development and treatment of metabolic diseases. Pharmacology & Therapeutics doi:10.1016/j.pharmthera.2017.03.007 (2017).
  3. F. Li, K.D. Howard, and M.J. Myers. Influence of P-glycoprotein on the disposition of fexofenadine and its enantiomers. Journal of Pharmacy and Pharmacology 69: 274-284 (2017).

  4. Y. Zhao, Y. Liu, X. Lan, G. Xu, Y. Sun, F. Li, H. Liu, Effect of Dendrobium officinale extraction on gastric carcinogenesis in Rats. Evidence-Based Complementary and Alternative Medicine doi:10.1155 (2016).

  5. Y. Xu, F. Li, M. Zalzala, J. Xu, F.J. Gonzalez, L. Adorini, Y. Lee, L. Yin, Y. Zhang. Farnesoid X Receptor Activation Increases Reverse Cholesterol Transport by Modulating Bile Acid Composition and Cholesterol Absorption in Mice. Hepatology 64:1072-1085 (2016). 
  6. Y. Zhang, X. Yang, X. Yang, W. Xu, F. Li, F.J. Gonzalez. Liquid Chromatography with Tandem Mass Spectrometry: A Sensitive Method for the Determination of dehydrodiisoeugenol in rat cerebral nuclei. Molecule 21: 321; doi:10.3390 (2016).
  7. J.W. Jones, C.L. Carter, F. Li, J. Yu, K. Pierzchalski, I.L. Jackson, Z. Vujaskovic, M.A. Kane. Ultraperformance convergence chromatography-high resolution tandem mass spectrometry for lipid biomarker profiling and identification. Biomedical Chromatography Aug 24 online (2016).
  8. F. Li, X. Yang, K. W. Krausz, R. G. Nichols, W. Xu, D. Patterson, F. J. Gonzalez. Modulation of colon cancer by nutmeg. Journal of Proteome Research 14: 1937-1946 (2015).
  9. C. Jiang, C. Xie, F. Li, L. Zhang, R.G. Nichols, K.W. Krausz, J. Cai, Y. Qi, Z.Z. Fang, S. Takahashi, N. Tanaka, D. Desai, S.G. Amin, I. Albert, A.D. Patterson, F.J. Gonzalez. Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease. Journal Clinical Investigation 125: 386-402 (2015).
  10. Y. Zhang, F. Li, Y. Wang, A. Pitre, Z. Fang, M.W. Frank, C. Calabrese, K.W. Krausz, G. Neale, S. Frase, P. Vogel, C. O. Rock, F.J. Gonzalez, J.D. Schuetz*. Maternal bile acid transporter deficiency promotes neonatal demise. Nat Commun, 2015, 6, 8186.
  11. G. Cao, W. Xu, X. Yang, F.J. Gonzalez, F. Li. New neolignans from the seeds of Myristica fragrans that inhibit nitric oxide production. Food Chemistry 15: 231-237 (2015).
  12. J.W. Jones, G. Tudor, F. Li, Y. Tong, B. Katz, A.M. Farese, T.J. MacVittie, C. Booth, M.A. Kane. Citrulline as a Biomarker in the Murine Total-Body Irradiation Model: Correlation of Circulating and Tissue Citrulline to Small Intestine Epithelial Histopathology. Health Physics 109:452-465 (2015).
  13. F. Li, C. Jiang, M. C. Larsen, J. Bushkofsky, K. W. Krausz, T. Wang, C. R. Jefcoate, and F. J. Gonzalez. Lipidomics reveals a link between CYP1B1 and SCD1 in promoting obesity. Journal of Proteome Research 13: 2679-2687 (2014).
  14. H. Bi, Y. Pan, J. Qiu, K.W. Krausz, F. Li, C. H. Johnson, C. Jiang, F.J. Gonzalez and A. Yu. N-methylnicotinamide and nicotinamide N-methyltransferase are associated with microRNA-1291 altered pancreatic carcinoma cell metabolome and suppressed tumorigenesis. Carcinogenesis 35: 2264-2272 (2014).
  15. F. Li, C. Jiang, A.D. Patterson, K.W. Krausz, I. Albert, H. Hao, K.M. Fabre, J.B. Mitchell, A.D. Patterson, and F.J. Gonzalez. Microbiome remodeling leads to inhibition of intestinal farnesoid X receptor signaling and decreased obesity. Nature Communications 4: 2384 (2013).
  16. F. Li, A.D. Patterson, K.W. Krausz, C. Jiang, H. Bi, A.L. Sowers, J.A. Cook, J.B. Mitchell, and F.J. Gonzalez. Metabolomics reveals that tumor xenografts induce liver dysfunction. Molecular & Cellular Proteomics 12:2126-2135 (2013).
  17. F. Li, X. Pang, K.W. Krausz, C. Jiang, C. Chen, J.A. Cook, M.C. Krishna, J.B. Mitchell, F.J. Gonzalez, and A.D. Patterson. Stable isotope- and mass spectrometry-based metabolomics as tools in drug metabolism: a study expanding tempol pharmacology. Journal of Proteome Research 12: 1369-1376 (2013).
  18. T. Matsubara, F. Li (Co-first author), and F.J. Gonzalez. FXR signaling in the enterohepatic system. Molecular and Cellular Endocrinology 368:17-29 (2013)
  19. C. Jiang, J. Kim, F. Li, A. Qu, O. Gavrilova, Y.M. Shah, and F.J. Gonzalez. Hypoxia-inducible factor 1α regulates a SOCS3-STAT3-adiponectin signal transduction pathway in adipocytes. Journal of Biological Chemistry 288: 3844-3857 (2013).
  20. H. Bi, K.W. Krausz, S.K. Manna, F. Li, C.H. Johnson, F.J. Gonzalez. Optimization of harvesting, extraction and analytical protocols for UPLC-ESI-MS-based metabolomic analysis of adherent mammalian cancer cells. Analytical and Bioanalytical Chemistry 405: 5276-5289 (2013).
  21. J. Horton, E.J. Chuang, F. Li, K. Hudak, A. White, K.W. Krausz, F.J. Gonzalez. Quercetin Inhibits Radiation-Induced Skin Fibrosis. Radiation Research 180: 205-215(2013)
  22. Z. Fang, K.W. Krausz, N. Tanaka, F. Li, A. Qu, F.J. Gonzalez. Metabolomics reveals trichloroacetate as a major contributor to trichloroethylene-induced metabolic alterations in mouse urine and serum. Archive of Toxicology 87:1975-1987 (2013).
  23. A.D. Patterson, B. Carlson, F. Li, J.A. Bonzo, M. Yoo, K.W. Krausz, M. Conrad, C. Chen, F.J. Gonzalez, and D.L. Hatfield. Disruption of thioredoxin reductase 1 Protects mice from acetaminophen-induced hepatotoxicity. Chemical Research in Toxicology 26: 1088-1096 (2013) (Cover paper)
  24. Y. Zhang, F. Li (Co-first author), A.D. Patterson, Y. Wang, K.W. Krausz, G. Neale, S. Thomas, D. Nachagar, P. Vogel, M. Vore, F.J. Gonzalez, and J.D. Schuetz. Abcb11 deficiency induces cholestasis coupled to impaired β-Fatty acid oxidation in mice. Journal of Biological Chemistry 287:24784-24794 (2012).
  25. F. Li, A.D. Patterson, K.W. Krausz, N. Tanaka, and F.J. Gonzalez. Metabolomics reveals an essential role for peroxisome proliferator-activated receptor α in bile acid homeostasis. Journal of Lipid Research 53: 1625-1635 (2012)
  26. F. Li, A.D. Patterson, K.W. Krausz, B. Dick, F.J. Frey, F.J. Gonzalez, and J.R. Idle. Metabolomics reveals the metabolic map of procainamide in humans and mice. Biochemical Pharmacology 83:1435-1444 (2012).
  27. F. Li. Metabolomics: One powerful tool for the understanding of xenobiotic receptors. Journal of Chromatography & Separation Techniques.3:e107 (2012). (Invited editorial)
  28. F. Li. Xenobiotic Metabolomics: An ideal tool for drug metabolism. Journal of Chromatography & Separation Techniques.3:e106 (2012). (Invited editorial)
  29. Z. Fang, K.W. Kristopher, F. Li, J. Cheng, N. Tanaka, and F.J. Gonzalez. Metabolic map and bioactivation of the anti-tumor drug noscapine. The British Journal of Pharmacology 167: (1271-1286) (2012).
  30. F. Li, A.D. Patterson, C.C. Höfer, K.W. Krausz, F.J. Gonzalez, and J.R. Idle. A comprehensive understanding of thioTEPA metabolism in the mouse using UPLC-ESI-QTOFMS-based metabolomics. Biochemical Pharmacology 81: 1043-1053 (2011).
  31. F. Li, A.D. Patterson, C.C. Höfer, K.W. Krausz, F.J. Gonzalez, and J.R. Idle. Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC-ESI-QTOFMS-based metabolomics. Biochemical Pharmacology 80:1063-1074 (2010).
  32. A.D. Patterson, J.A. Bonzo, F. Li, K.W. Krausz, G.S. Eichler, S. Aslam, X. Tigno, J.N. Weinstein, B.C. Hansen, J.R. Idle, and F.J. Gonzalez. Metabolomics reveals attenuation of the SLC6A20 kidney transporter in nonhuman primate and mouse models of type 2 diabetes mellitus. Journal of Biological Chemistry 22: 19511-19522 (2011).
  33. A.D. Patterson, O. Slanar, K.W. Krausz, F. Li, C.C. Höfer, F. Perlík, F.J. Gonzalez, and J.R. Idle. Human Urinary metabolomic profile of PPARa induced fatty acid b-oxidation. Journal of Proteome Research 8: 4293-300 (2009).

 REPRESENTATIVE PUBLICATIONS
  1. F. Li, W. Zhu, F.J. Gonzalez. Potential role of CYP1B1 in the development and treatment of metabolic diseases. Pharmacology & Therapeutics doi:10.1016/j.pharmthera.2017.03.007 (2017). IF = 11.0
  2. Y. Xu, F. Li, M. Zalzala, J. Xu, F.J. Gonzalez, L. Adorini, Y. Lee, L. Yin, Y. Zhang. Farnesoid X Receptor Activation Increases Reverse Cholesterol Transport by Modulating Bile Acid Composition and Cholesterol Absorption in Mice. Hepatology 64:1072-1085 (2016). IF = 11.7
  3. C. Jiang, C. Xie, F. Li, L. Zhang, R.G. Nichols, K.W. Krausz, J. Cai, Y. Qi, Z.Z. Fang, S. Takahashi, N. Tanaka, D. Desai, S.G. Amin, I. Albert, A.D. Patterson, F.J. Gonzalez. Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease. Journal Clinical Investigation 125: 386-402 (2015). IF = 13.2
  4. Y. Zhang, F. Li, Y. Wang, A. Pitre, Z. Fang, M.W. Frank, C. Calabrese, K.W. Krausz, G. Neale, S. Frase, P. Vogel, C. O. Rock, F.J. Gonzalez, J.D. Schuetz*. Maternal bile acid transporter deficiency promotes neonatal demise. Nat Commun, 2015, 6, 8186. IF = 11.5
  5. F. Li, C. Jiang, A.D. Patterson, K.W. Krausz, I. Albert, H. Hao, K.M. Fabre, J.B. Mitchell, A.D. Patterson, and F.J. Gonzalez. Microbiome remodeling leads to inhibition of intestinal farnesoid X receptor signaling and decreased obesity. Nature Communications 4: 2384 (2013). IF = 11.4

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