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State Key Laboratory of Phytochemistry and Plant Resources in West China
CHEN Jijun's Group
CHENG Yongxian's Group
HAO Xiaojiang's Group
LIU Jikai's Group
LUO Xiaodong's Group
QIU Minghua's Group
ZENG Ying's Group
SUN Handong's Group
TAN Ninghua's Group
ZHANG Yingjun's Group
ZHAO Qinshi's Group
LUO Huairong's Group
LI Yan's Group
LI Shenghong's Group
YANG Yurong's Group
XIA Chengfeng's Group
ZHAO Jinhua's Group
QIN Hongbo's Group
WU Bin's Group
XU Gang's Group
ZHOU Jun's Group
LIU Haiyang's Group
XIONG Wenyong's Group
HU Kaifeng's Group
LI Fei's Group
Location: Home > State Key Laboratory of Phytochemistry and Plant Resources in West China > LUO Huairong's Group > Major Research Achievements
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Major Research Achievements
source:     author:     2012-08-09

Over the past three years our group has worked on several facets of drug screening and research in treating neuropsychiatric diseases. Our studies encompass four areas. First, we systematically screened about 1,000 compounds from TCMs against neuropsychiatric disease and found about 50 compounds with potent bioactivity in molecular, cellular and animal models. Second, we demonstrated that the lead compounds modulated the cellular level of second messengers (cAMP, Ca2+) involved the neurotrophin signaling pathway that might potently modulate neurogenesis. Third, we spent significant effort to elucidate the molecular basis of how the chlorogenic acid to extend lifespan in Caenorhabditis elegans.Lastly, our recent studies have contributed to the hypothesis that ion channel modulators might serve as lead compounds for treating neuropsychiatric diseases.


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