1. The biosynthetic origin of vibralactone in the basidiomycete fungus Boreostereum vibrans and evidence for its biosynthetic pathway which includes several very interesting reactions which may involve unusual enzymes (Angewandte Chemie International Edition 2013, 52, 2298-2302)

   

 

  

   2. A FAD-binding monooxygenase VibMO1 that converts prenyl 4-hydroxybenzoate into prenylhydroquinone and a divergent pathway to skeletally distinct meroterpenoids in B. vibrans from a common intermediate that has a shikimate-terpenoid origin, based on the traditional platform of precursor-directed biosynthesis and the analogous intermediates resulted (Angewandte Chemie International Edition 2016, 55: 5463–5466；http://onlinelibrary.wiley.com/doi/10.1002/anie.201510928/abstract) 

 

 

 

 

　　　　　　

　　3. Biosynthesis of pharmacologically active Isodon ent-kaurane diterpenoids

　　    Ent-kaurane diterpenoids, isolated from the Chinese medicinal herbs, Isodon L., are principle components showing potent bioactivities of antitumor and anti-autoimmune inflammation. We have cloned IeCPS1 and IeCPS2 encoding ent-copalyl diphosphate synthases (CPS) and verified that IeCPS1 and IeCPS2 are potentially involved in the biosynthesis of Isodon diterpenoids (Phytochemistry 2012, 76, 32-39).